Reactivation of persistent papovavirus K infection in immunosuppressed mice
نویسندگان
چکیده
منابع مشابه
Reactivation of persistent papovavirus K infection in immunosuppressed mice.
Papovavirus K (K virus) is a murine papovavirus that produces a fatal interstitial pneumonia in newborn mice and a clinically inapparent infection in older animals. The present study was conducted to determine whether the virus produces latent infection in animals surviving acute infection and whether the infection can be reactivated by immunosuppression. Mice were inoculated by the oral route ...
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The fatal outcome of K virus infection in infant mice and cytoxan-treated adult mice is related to their inability to mount a prompt antibody response to the virus. Athymic nude mice infected with K virus exhibited no clinical illness and no detectable virus-specific immunoglobulin G (IgG) response, but they did exhibit a low level of virus-specific immunoglobulin M response. Transfer of spleen...
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Intraperitoneal inoculation of mouse K papovavirus into infant (2 to 4 days old) Swiss albino mice produced a high-titered viremia which persisted until death due to pneumonitis on day 9 postinfection. Lungs and livers of these mice had virus-specific immunofluorescence and histological lesions. K-virus antibody was undetectable. Three- to four-week-old mice, although as susceptible to infectio...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1984
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.51.2.425-429.1984